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Structure of medicinal chemistry Corwin Hansch pp 1 - 6; DOI: 10.1021/jm00223a001 |
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Synthesis and adrenoreceptor blocking action of aziridinium ions derived from phenoxybenzamine and dibenamine James G. Henkel, Philip S. Portoghese, Jack W. Miller, and Patricia Lewis pp 6 - 10; DOI: 10.1021/jm00223a002 |
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Importance of the aromatic ring in adrenergic amines. 2. Synthesis and adrenergic activity of some nonaromatic six- and eight-membered ring analogs of .beta.-phenylethanolamine Gary L. Grunewald, Joseph M. Grindel, Popat N. Patil, and Kadhim N. Salman pp 10 - 16; DOI: 10.1021/jm00223a003 |
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Relation between analgetic ED50 dose and time-course brain levels of N-alkylnormeperidine homologs Dennis L. Larson and Philip S. Portoghese pp 16 - 19; DOI: 10.1021/jm00223a004 |
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Specificity of an antibody directed against d-methamphetamine. Rigid and nonrigid analogs Bahjat A. Faraj, Zafar H. Israili, Nancy E. Kight, Edward E. Smissman, and Thomas L. Pazdernik pp 20 - 25; DOI: 10.1021/jm00223a005 |
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Aporphines. 14. Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10-hydroxyaporphines and 10-hydroxy-N-propylnoraporphine J. L. Neumeyer, J. F. Reinhard, W. P. Dafeldecker, J. Guarino, D. S. Kosersky, K. Fuxe, and L. Agnati pp 25 - 29; DOI: 10.1021/jm00223a006 |
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Catechol O-methyltransferase. 7. Affinity labeling with the oxidation products of 6-aminodopamine Ronald T. Borchardt, Edward E. Smissman, Donald Nerland, and Jack R. Reid pp 30 - 37; DOI: 10.1021/jm00223a007 |
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Potential oxidative pathways of brain catecholamines Daniel C. S. Tse, Richard L. McCreery, and Ralph N. Adams pp 37 - 40; DOI: 10.1021/jm00223a008 |
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8-Chloro-(S)- and -(R)-10-[(S)- and -(R)-3'-methylethylaminopyrrolidino]-10,11-dihydrodibenzo[b,f]thiepins. Synthesis and pharmacological studies Donald T. Witiak, Babu R. Vishnuvajjala, Tribhuwan K. Gupta, and Michael C. Gerald pp 40 - 47; DOI: 10.1021/jm00223a009 |
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Novel analogs of tricyclic psychopharmacological agents Karen E. Eichstadt, John C. Reepmeyer, Richard B. Cook, Paul G. Riley, Dwight P. Davis, and Robert A. Wiley pp 47 - 51; DOI: 10.1021/jm00223a010 |
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Conformational study of .beta.-phenethanolamine receptor sites. 8. Pharmacological study of 3-isopropylamino-2-phenyl-trans-2-decalols M. Hava, J. Bernstein, E. E. Smissman, and S. El-Antably pp 52 - 54; DOI: 10.1021/jm00223a011 |
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Stereochemical studies on medicinal agents. 19. The x-ray crystal structures of two (+-)-allylprodine diastereomers. Role of the allyl group in conferring high stereoselectivity and potency at analgetic receptors Philip S. Portoghese and Eli Shefter pp 55 - 57; DOI: 10.1021/jm00223a012 |
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Chemistry and antibacterial activity of nitrobenzofurans Larry J. Powers pp 57 - 62; DOI: 10.1021/jm00223a013 |
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Correlation analysis of Baker's studies on enzyme inhibition. 1. Guanine deaminase, xanthine oxidase, dihydrofolate reductase, and complement Carlo Silipo and Corwin Hansch pp 62 - 71; DOI: 10.1021/jm00223a014 |
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Correlation analysis of Baker's studies on enzyme inhibition. 2. Chymotrypsin, trypsin, thymidine phosphorylase, uridine phosphorylase, thymidilate synthetase, cytosine nucleoside deaminase, dihydrofolate reductase, malate, glutamate, lactate, and glyceraldehyde-phosphate dehydrogenase Masafumi Yoshimoto and Corwin Hansch pp 71 - 98; DOI: 10.1021/jm00223a015 |
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Ergoline congeners as potential inhibitors of prolactin release 2 David B. Rusterholz, Charles F. Barfknecht, and James A. Clemens pp 99 - 102; DOI: 10.1021/jm00223a016 |
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Improved delivery through biological membranes. 1. Synthesis and properties of 1-methyl-1,6-dihydropyridine-2-carbaldoxime, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride Nicolae Bodor, Efraim Shek, and Takeru Higuchi pp 102 - 107; DOI: 10.1021/jm00223a017 |
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Improved delivery through biological membranes. 2. Distribution, excretion, and metabolism of N-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride Efraim Shek, Takeru Higuchi, and Nicolae Bodor pp 108 - 112; DOI: 10.1021/jm00223a018 |
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Improved delivery through biological membranes. 3. Delivery of N-methylpyridinium-2-carbaldoxime chloride through the blood-brain barrier in its dihydropyridine pro-drug form Efraim Shek, Takeru Higuchi, and Nicolae Bodor pp 113 - 117; DOI: 10.1021/jm00223a019 |
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Conformationally restricted analogs of histamine H1 receptor antagonists, trans- and cis-1-benzyl-3-dimethylamino-6-phenylpiperidine Ahmed E. Ahmed, Patrick E. Hanna, and Vernon R. Grund pp 117 - 122; DOI: 10.1021/jm00223a020 |
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Synthesis and biological actions of 2-substituted quinolizidines Thomas L. Lemke and Michael B. Cramer pp 122 - 126; DOI: 10.1021/jm00223a021 |
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Synthesis and biological activity of 2- and 4-substituted 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines Edward E. Smissman, Jack R. Reid, David A. Walsh, and Ronald T. Borchardt pp 127 - 131; DOI: 10.1021/jm00223a022 |
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Comparative analysis of the cytotoxicity of substituted [phenylglyoxal bis(4-methyl-3-thiosemicarbazone]copper(II) chelates Eugene A. Coats, Stanley R. Milstein, Gary Holbein, Joh McDonald, Ronald Reed, and Harold G. Petering pp 131 - 135; DOI: 10.1021/jm00223a023 |
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Copper chelates as possible active forms of the antiarthritic agents John R. J. Sorenson pp 135 - 148; DOI: 10.1021/jm00223a024 |
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Podophyllotoxin analogs. 1. Synthesis and biological evaluation of certain trans-2-aryl-trans-6-hydroxymethyl-3-cyclohexenecarboxylic acid .gamma.-lactones as antimitotic agents Edward E. Smissman, Robert J. Murray, James D. McChesney, L. L. Houston, and Thomas L. Pazdernik pp 148 - 153; DOI: 10.1021/jm00223a025 |
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Stereochemical analogs of a muscarinic, ganglionic stimulant. 2. The cis and trans olefinic, epoxide, and cyclopropane analogs related to 4-[N-(3-chlorophenyl)carbamoyloxy]-2-butynyltrimethylammonium chloride W. L. Nelson, D. S. Freeman, and F. F. Vincenzi pp 153 - 158; DOI: 10.1021/jm00223a026 |
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Stereochemical analogs of a muscarinic, ganglionic stimulant. 3. 2,3-Substituted bicyclo[2.2.1]hept-5-enes and -heptanes related to 4-[N-(3-chlorophenyl)carbamoyloxy]-2-butynyltrimethylammonium chloride W. L. Nelson, D. S. Freeman, and F. F. Vincenzi pp 159 - 160; DOI: 10.1021/jm00223a027 |
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Specificity in enzyme inhibition. 3. Synthesis of 5-substituted-2,2-dimethyl-4-imidazolidinones as inhibitors of tyrosine decarboxylase and histidine decarboxylase Edward E. Smissman, Roger L. Inloes, Samir El-Antably, and Phyllis J. Shaffer pp 161 - 163; DOI: 10.1021/jm00223a028 |
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Synthesis and evaluation of brain catecholamine depletion by N-alkyl derivatives of 6-aminodopamine Donald E. Nerland and Edward E. Smissman pp 163 - 164; DOI: 10.1021/jm00223a029 |
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Synthesis of inhibitors of bacterial cell wall biogenesis. Analogs of D-alanyl-D-alanine Edward E. Smissman, Atsusuke Terada, and Samir El-Antably pp 165 - 167; DOI: 10.1021/jm00223a030 |
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Synthesis and in vitro evaluation of 8-hydroxyquinoline analogs as inhibitors of dental plaque Victor D. Warner, Jayant N. Sane, Dale B. Mirth, Samuel S. Turesky, and Barbara Soloway pp 167 - 169; DOI: 10.1021/jm00223a031 |
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Difference in antimalarial activity between certain amino alcohol diastereomers Ping-Lu Chien and C. C. Cheng pp 170 - 172; DOI: 10.1021/jm00223a032 |
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Synthesis and antiinflammatory properties of N-substituted 4,5-dioxopyrrolidine-3-carboxanilides Saul B. Kadin pp 172 - 173; DOI: 10.1021/jm00223a033 |
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Effect of aromatic nitro compounds on oxidative metabolism by cytochrome P-450 dependent enzymes Larry A. Sternson and Richard E. Gammans pp 174 - 177; DOI: 10.1021/jm00223a034 |
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Intracyclization rates of 6-hydroxydopamine and 6-aminodopamine analogs under physiological conditions C. L. Blank, Richard L. McCreery, R. M. Wightman, W. Chey, Ralph N. Adams, J. R. Reid, and Edward E. Smissman pp 178 - 180; DOI: 10.1021/jm00223a035 |
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Stereochemical studies of adrenergic drugs. Diastereomeric 2-amino-1-phenylcyclobutanols Duane D. Miller, Fu-Lian Hsu, Kadhim N. Salman, and Popat N. Patil pp 180 - 184; DOI: 10.1021/jm00223a036 |
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7-Aza analogs of the analgetic agent azabicyclane. Synthesis and pharmacologic analysis Edward E. Smissman and Peter C. Ruenitz pp 184 - 186; DOI: 10.1021/jm00223a037 |
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Adamantanamine derivatives. Antimicrobial activities of certain Mannich bases Robert A. Magarian and William G. Sorenson pp 186 - 189; DOI: 10.1021/jm00223a038 |
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2,3-Dihydroxyphenethanolamine as an adrenergic agent R. Martin Bartholow and Edward J. Walaszek pp 189 - 190; DOI: 10.1021/jm00223a039 |
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Amino acids. 1. .alpha.-Hydroxymethylphenylalanines Richard A. Schnettler, John T. Suh, and Richard C. Dage pp 191 - 192; DOI: 10.1021/jm00223a040 |
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Central nervous system depressants. 13. s-Triazolo-1,5-benzodiazepin-5-ones Robert B. Moffett, Bharat V. Kamdar, and P. F. Von Voigtlander pp 192 - 193; DOI: 10.1021/jm00223a041 |
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Synthesis of 5-substituted uracil derivatives Eric C. Ressner, Phillip Fraher, Marshall S. Edelman, and Mathias P. Mertes pp 194 - 196; DOI: 10.1021/jm00223a042 |
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S-aristeromycinyl-L-homocysteine, a potent inhibitor of S-adenosylmethionine-dependent transmethylations Ronald T. Borchardt and Yih-Shiong Wu pp 197 - 198; DOI: 10.1021/jm00223a043 |
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Inhibitors of the luteinizing hormone-releasing hormone based upon modifications in the 2, 3, and 6 positions Yieh-Ping Wan, John Humphries, George Fisher, Karl Folkers, and Cyril Y. Bowers pp 199 - 202; DOI: 10.1021/jm00224a001 |
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Synthesis and evaluation of 1,.omega.-diaryl-1,.omega.-alkanediamines related to the fibrinolytic bis(tetrahydroisoquinolines) and bis(benzylamines) Leonard J. Fliedner, Melvyn J. Myers, Joseph M. Schor, and Irwin J. Pachter pp 202 - 208; DOI: 10.1021/jm00224a002 |
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Basic derivatives of 6,7-dihydroindolo[1,7-ab][1]benzazepine and 6H-indolo[7,1-cd][1,5]benzoxazepine as potential antidepressant agents Luciano Toscano, Giampiero Grisanti, Giuseppe Fioriello, Ennio Seghetti, Alberto Bianchetti, Giuseppe Bossoni, and Mario Riva pp 208 - 213; DOI: 10.1021/jm00224a003 |
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Preparation and in vitro antifungal activities of some quinolizidine derived hemiaminals and .beta.-tert-amino sulfides Robert T. LaLonde, Amy I. M. Tsai, Chun Juan Wang, Chunfook Wong, and Gigi Lee pp 214 - 219; DOI: 10.1021/jm00224a004 |
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Cycloalkanones. 8. Hypocholesterolemic activity of long-chain ketones related to pentadecanone Steven D. Wyrick, Iris H. Hall, Claude Piantadosi, and Charles R. Fenske pp 219 - 222; DOI: 10.1021/jm00224a005 |
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Hypocholesterolemic activity of 1,3-bis(substituted phenoxy)-2-propanones Claude Piantadosi, Iris H. Hall, Steven D. Wyrick, and Khalid S. Ishaq pp 222 - 229; DOI: 10.1021/jm00224a006 |
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Novel pyrazolo, isoxazolo, and thiazolo steroidal systems and model analogs containing dimethoxylaryl (or dihydroxylaryl) groups and derivatives. Synthesis, spectral properties, and biological activity M. M. Hashem, K. D. Berlin, R. W. Chesnut, and N. N. Durham pp 229 - 239; DOI: 10.1021/jm00224a007 |
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Synthesis and structure-activity relations of heterocyclic compounds containing a trimethoxyarene function E. A. Mawdsley, K. D. Berlin, R. W. Chesnut, and N. N. Durham pp 239 - 243; DOI: 10.1021/jm00224a008 |
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Synthesis of angiotensin II antagonists containing N- and O-methylated and other amino acid residues M. C. Khosla, H. Munoz-Ramirez, M. M. Hall, R. R. Smeby, P. A. Khairallah, F. M. Bumpus, and M. J. Peach pp 244 - 250; DOI: 10.1021/jm00224a009 |
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Synthesis and some pharmacological properties of five analogs of oxytocin having L-homocysteine in position 6 Clark W. Smith and Martha F. Ferger pp 250 - 254; DOI: 10.1021/jm00224a010 |
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Synthesis and biological inactivity of some 4.alpha.,6-cyclo steroids F. Thomas Bond, Walter Weyler, Bernard Brunner, and Jeffrey E. Stemke pp 255 - 259; DOI: 10.1021/jm00224a011 |
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Synthesis and pharmacology of 2,9.alpha.-dimethyl-2'-hydroxy-6,7-benzomorphan Hirozumi Inoue and Everette L. May pp 259 - 262; DOI: 10.1021/jm00224a012 |
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Interferon inducing activities of derivatives of 1,3-dimethyl-4-(3-dimethylaminopropylamino)-1H-pyrazolo[3,4-b]quinoline and related compounds R. R. Crenshaw, George M. Luke, and Paul Siminoff pp 262 - 275; DOI: 10.1021/jm00224a013 |
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Antifertility agents. 12. Structure-activity relation of 3,4-diphenylchromenes and -chromans Suprabhat Ray, Payara K. Grover, Ved P. Kamboj, B. S. Setty, Amiya B. Kar, and Nitya Anand pp 276 - 279; DOI: 10.1021/jm00224a014 |
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Relation of molecular structure to in vivo scintigraphic distribution patterns of carbon-11-labeled compounds. 3. Carbon-11-labeled hydantoins Meldrum B. Winstead, Shelley J. Parr, Michael J. Rogal, Paul S. Brockman, Ronald Lubcher, Archie Khentigan, Tz-Hong Lin, James F. Lamb, and H. Saul Winchell pp 279 - 286; DOI: 10.1021/jm00224a015 |
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Synthesis of tetrazole ribonucleosides and their evaluation as antiviral agents Mohindar S. Poonian, Eugene F. Nowoswiat, John F. Blount, Thomas H. Williams, Ross G. Pitcher, and Michael J. Kramer pp 286 - 290; DOI: 10.1021/jm00224a016 |
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Synthesis and enzymic activity of some novel xanthine oxidase inhibitors. 3-Substituted 5,7-dihydroxypyrazolo[1,5-a]pyrimidines Robert H. Springer, Mary K. Dimmitt, Thomas Novinson, Darrell E. O'Brien, Roland K. Robins, Lionel N. Simon, and Jon P. Miller pp 291 - 296; DOI: 10.1021/jm00224a017 |
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Immobilized glucuronosyltransferase for the synthesis of conjugates Indu Parikh, Donald W. MacGlashan, and Catherine Fenselau pp 296 - 299; DOI: 10.1021/jm00224a018 |
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Chemistry and biological activities of N,N-dimethylaminoethyl acrylate, a choline acetyltransferase inhibitor Peter P. Rowell and C. Y. Chiou pp 300 - 303; DOI: 10.1021/jm00224a019 |
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Antiinflammatory activity of some 2,3-dihydrobenzofuran-5-acetic acids and related compounds Noriyasu Hirose, Shizuo Kuriyama, Yoshinori Kato, and Shoji Toyoshima pp 303 - 308; DOI: 10.1021/jm00224a020 |
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Potential antitumor agents. Synthesis of bifunctional .alpha.-methylene-.gamma.-butyrolactones Gary A. Howie, Ioannis K. Stamos, and John M. Cassady pp 309 - 313; DOI: 10.1021/jm00224a021 |
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Potential central nervous system antitumor agents. Aziridinylbenzoquinones. 1 A. Hameed Khan and John S. Driscoll pp 313 - 317; DOI: 10.1021/jm00224a022 |
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Carboxyarylindoles as nonsteroidal antiinflammatory agents V. Brian Anderson, Marc N. Agnew, Richard C. Allen, Jeffrey C. Wilker, Howard B. Lassman, and William J. Novick pp 318 - 325; DOI: 10.1021/jm00224a023 |
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Hypothalamic hormones. 71. Synthesis and some biological activities of the tyrosine-8 analog of substance P George H. Fisher, Karl Folkers, Bengt Pernow, and Cyril Y. Bowers pp 325 - 328; DOI: 10.1021/jm00224a024 |
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Synthetic metabolites of neurohypophyseal hormones. [Des-9-glycinamide]oxytocin and [des-9-glycinamide,des-8-leucine]oxytocin Roderich Walter, Robert T. Havran, and I. L. Schwartz pp 328 - 330; DOI: 10.1021/jm00224a025 |
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.beta.-Lactam antibiotics with N-oxide side chains. 1. Quinoxaline N-oxides M. L. Edwards, R. E. Bambury, and H. W. Ritter pp 330 - 333; DOI: 10.1021/jm00224a026 |
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Synthesis and pharmacological evaluation of some 3-substituted octahydropyrido[2,1-c][1,4]oxazines Thomas N. Riley and Gary O. Rankin pp 334 - 336; DOI: 10.1021/jm00224a027 |
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Synthesis of N-hydroxythiourea Masayuki Sato and Charles H. Stammer pp 336 - 337; DOI: 10.1021/jm00224a028 |
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Substituted naphthazarins as potential anticancer agents Kenneth D. Paull, Robert K. Y. Zee-Cheng, and C. C. Cheng pp 337 - 339; DOI: 10.1021/jm00224a029 |
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Inhibition of tumor cell transplantability by iron and copper complexes of 5-substituted 2-formylpyridine thiosemicarbazones William E. Antholine, Judith M. Knight, and David H. Petering pp 339 - 341; DOI: 10.1021/jm00224a030 |
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Racemic diastereoisomers of 1-amino-2-hydroxycyclopentanecarboxylic acid Dimitri E. Gaitanopoulos, James Nash, Danny L. Dunn, and Charles G. Skinner pp 342 - 344; DOI: 10.1021/jm00224a031 |
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Synthesis of 5-substituted aminomethyluracils via the Mannich reaction Thomas J. Delia, John P. Scovill, William D. Munslow, and Joseph H. Burckhalter pp 344 - 346; DOI: 10.1021/jm00224a032 |
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Products from furans. 1. Synthesis and anticoccidial and antimicrobial activity of 5-amino-5,6-dihydro-6-methoxy-2-methyl-2-(4'-biphenylyl)-2H-pyran-3(4H)-ones and related compounds Minas P. Georgiadis pp 346 - 349; DOI: 10.1021/jm00224a033 |
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Anthelmintic 1-cinnamamido-2,4-imidazolidinediones Robert J. Alaimo and Christopher J. Hatton pp 349 - 350; DOI: 10.1021/jm00224a034 |
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Book Reviews pp 350 - 352; DOI: 10.1021/jm00224a600 |
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Synthesis of a potential water-soluble radiographic contrast medium, 2,4,6-triiodo-3-acetamido-5-N-methylcarboxamidophenyl .beta.-D-glucopyranoside F. L. Weitl, M. Sovak, and M. Ohno pp 353 - 356; DOI: 10.1021/jm00225a001 |
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Radiopharmaceuticals. 16. Halogenated dopamine analogs. Synthesis and radiolabeling of 6-iododopamine and tissue distribution studies in animals J. S. Fowler, R. R. MacGregor, A. P. Wolf, A. N. Ansari, and H. L. Atkins pp 356 - 360; DOI: 10.1021/jm00225a002 |
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Antimalarials. 8. Synthesis of amino ethers as candidate antimalarials M. P. LaMontagne, M. S. Ao, A. Markovac, and J. R. Menke pp 360 - 365; DOI: 10.1021/jm00225a003 |
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Hypoglycemic .alpha.-cycloalkylphenylmethyl, furanalkyl, and thiophenealkyl lactamimides J. Martin Grisar, George P. Claxton, and Norbert L. Wiech pp 365 - 369; DOI: 10.1021/jm00225a004 |
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Synthesis and biological activity of new 2-substituted analogs of fluphenazine Paul C. Bossle, C. Parker Ferguson, Walter E. Sultan, Willard J. Lennox, Gaston E. Dudley, Thomas H. Rea, and Jacob I. Miller pp 370 - 373; DOI: 10.1021/jm00225a005 |
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Synthesis and biological activity of camel and bovine .beta.-melanotropins Simon Lemaire, Donald Yamashiro, and Choh Hao Li pp 373 - 376; DOI: 10.1021/jm00225a006 |
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Synthesis and some pharmacological properties of [1-(L-2-hydroxy-3-mercaptopropanoic acid),4-threonine]oxytocin (hydroxy[4-thr]oxytocin), a peptide with strikingly high oxytocic potency, and of [1-(L-2-hydroxy-3-mercaptopropanoic acid)]oxytocin (hydroxy-oxytocin) Maurice Manning, John Lowbridge, Jaya Haldar, and Wilbur H. Sawyer pp 376 - 380; DOI: 10.1021/jm00225a007 |
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Structure-activity relation of daunorubicin and its peptide derivatives David W. Wilson, Douglas Grier, Ronald Reimer, Jeffrey D. Bauman, James F. Preston, and Edmond J. Gabbay pp 381 - 384; DOI: 10.1021/jm00225a008 |
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Physicochemical and pharmacological studies of some 8-substituted decahydroisoquinolines Ian W. Mathison, Phillip H. Morgan, Norbert J. Wojciechowski, Jack P. Bandura, and James R. Wennemark pp 385 - 391; DOI: 10.1021/jm00225a009 |
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Etodolic acid and related compounds. Chemistry and antiinflammatory actions of some potent di- and trisubstituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids Christopher A. Demerson, Leslie G. Humber, Adolph H. Philipp, and Rene R. Martel pp 391 - 395; DOI: 10.1021/jm00225a010 |
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Adriamycin analogs. Periodate oxidation of adriamycin George Tong, William W. Lee, Douglas R. Black, and David W. Henry pp 395 - 398; DOI: 10.1021/jm00225a011 |
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New series of cardioselective adrenergic .beta.-receptor blocking compounds. 1-(2-Acyl-4-acylaminophenoxy)-3-isopropylaminopropan-2-ols B. Basil, J. R. Clark, E. C. J. Coffee, R. Jordan, A. H. Loveless, D. L. Pain, and K. R. H. Wooldridge pp 399 - 402; DOI: 10.1021/jm00225a012 |
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Aminobenzoic acid diuretics. 8. 3,4-Disubstituted 5-methylsulfonylbenzoic acids and related compounds Peter W. Feit and Ole B. Tvaermose Nielsen pp 402 - 406; DOI: 10.1021/jm00225a013 |
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Antimalarials. 11. 2-Vinylogs of substituted 2-aryl-4-quinoline amino alcohols Robert E. Lutz and J. Milton Sanders pp 407 - 410; DOI: 10.1021/jm00225a014 |
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Conformational influence of a 19-methyl substituent in 19-oxygenated steroid structures Douglas C. Rohrer, Charles M. Weeks, Yoshio Osawa, and William L. Duax pp 410 - 414; DOI: 10.1021/jm00225a015 |
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Contraceptive agents from cycloaddition reactions of diarylcyclopropenones and diarylthiirene 1,1-dioxides Melvin H. Rosen, Ingrid Fengler, Georgina Bonet, Thomas Giannina, Margaret C. Butler, Fred R. Popick, and Bernard G. Steinetz pp 414 - 419; DOI: 10.1021/jm00225a016 |
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Synthesis of some 1,8- and 2,8-disubstituted derivatives of adenosine cyclic 3',5'-phosphate and their interaction with some enzymes of cAMP metabolism Hitoshi Uno, Rich B. Meyer, Dennis A. Shuman, Roland K. Robins, Lionel N. Simon, and Jon P. Miller pp 419 - 422; DOI: 10.1021/jm00225a017 |
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Analogs of luteinizing hormone-releasing hormone with increased biological activity produced by D-amino acid substitutions in position 6 David H. Coy, Jesus A. Vilchez-Martinez, Esther J. Coy, and Andrew V. Schally pp 423 - 425; DOI: 10.1021/jm00225a018 |
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Synthesis of the antileukemic compound N,N''-[5-[bis(2-chloroethyl)amino]-1,3-phenylene]bisurea George H. Denny, Malcolm A. Ryder, Anthony M. De Marco, and Robert D. Babson pp 426 - 428; DOI: 10.1021/jm00225a019 |
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Synthesis and microbiological activities of .beta.-(1-chloro-2-naphthyl)alanine and .beta.-(1-bromo-2-naphthyl)alanine Tommy J. McCord, Richard N. Watson, Clifton E. DuBose, Karen L. Hulme, and Alvie L. Davis pp 429 - 430; DOI: 10.1021/jm00225a020 |
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Optical resolution of (+-)-2,5-dimethyl-2'-hydroxy-9.alpha.- and -9.beta.-propyl-6,7-benzomorphans and their pharmacological properties Kenner C. Rice and Arthur E. Jacobson pp 430 - 432; DOI: 10.1021/jm00225a021 |
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Structure and antitumor activity relation of 2-arylidene-4-cyclopentene-1,3-diones and 2-arylideneindan-1,3-diones Seiichi Inayama, Katsuhiro Mamoto, Tetsuichi Shibata, and Tadaaki Hirose pp 433 - 436; DOI: 10.1021/jm00225a022 |
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Synthesis and central nervous system depressant activity of some bicyclic amides Paul Aeberli, John H. Gogerty, William J. Houlihan, and Louis C. Iorio pp 436 - 438; DOI: 10.1021/jm00225a023 |
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Potentiation of the estrogenic activity of stilbestrol by spiro(cyclohexane-1,2'-indan)-1',4-dione David J. Bailey, Neil S. Doggett, Lai Yin Ng, and Tariq Qazi pp 438 - 439; DOI: 10.1021/jm00225a024 |
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Book Reviews pp 439 - 444; DOI: 10.1021/jm00225a600 |
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Drugs derived from cannabinoids. 1. Nitrogen analogs, benzopyranopyridines and benzopyranopyrroles Harry G. Pars, Felix E. Granchelli, Raj K. Razdan, Jacqueline K. Keller, David G. Teiger, Franklin J. Rosenberg, and Louis S. Harris pp 445 - 454; DOI: 10.1021/jm00226a001 |
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Drugs derived from cannabinoids. 2. Basic esters of nitrogen and carbocyclic analogs Raj K. Razdan, B. Zitko Terris, Harry G. Pars, Nicholas P. Plotnikoff, Patrick W. Dodge, Anthony T. Dren, Jaroslav Kyncl, and Peter Somani pp 454 - 461; DOI: 10.1021/jm00226a002 |
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Drugs derived from cannabinoids. 5. .DELTA.6a,10a,-Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains Martin Winn, David Arendsen, Patrick W. Dodge, Anthony Dren, Daniel Dunnigan, Robert Hallas, Kao Hwang, Jaroslav Kyncl, Yien-Hwei Lee, and et al. pp 461 - 471; DOI: 10.1021/jm00226a003 |
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Monoquaternary neuromuscular blocking agents based on 1-tetralone and 1-indanone D. F. Biggs, A. F. Casy, Ih Chu, and R. T. Coutts pp 472 - 475; DOI: 10.1021/jm00226a004 |
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Analgesic agents. 3. New bridged aminotetralins Meier E. Freed, John R. Potoski, Elisabeth H. Freed, George L. Conklin, and Stanley C. Bell pp 476 - 480; DOI: 10.1021/jm00226a005 |
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Azaparacyclophanes. Novel class of conformationally rigid analogs of phenylethylamine and phenylpropylamine Kent E. Opheim, Adolph P. Roszkowski, Marshall B. Wallach, and Ian T. Harrison pp 480 - 483; DOI: 10.1021/jm00226a006 |
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Mode of action and quantitative structure-activity correlations of tuberculostatic drugs of the isonicotinic acid hydrazide type Joachim K. Seydel, Klaus J. Schaper, Ellen Wempe, and Hans P. Cordes pp 483 - 492; DOI: 10.1021/jm00226a007 |
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Structure-activity relationships in luteinizing hormone-releasing hormone Kari U. Prasad, Roger W. Roeske, Frederick L. Weitl, Jesus A. Vilchez-Martinez, and Andrew V. Schally pp 492 - 495; DOI: 10.1021/jm00226a008 |
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Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs Tai-Shun Lin, John P. Neenan, Yung-Chi Cheng, William H. Prusoff, and David C. Ward pp 495 - 498; DOI: 10.1021/jm00226a009 |
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Inhibition of separated forms of phosphodiesterases from pig coronary arteries by uracils and by 7-substituted derivatives of 1-methyl-3-isobutylxanthine J. E. Garst, G. L. Kramer, Y. J. Wu, and J. N. Wells pp 499 - 503; DOI: 10.1021/jm00226a010 |
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Substituted .alpha.-methylbenzyl and tricyclic arylalkyl lactamimides as inhibitors of blood platelet aggregation J. Martin Grisar, George P. Claxton, and Robert D. MacKenzie pp 503 - 508; DOI: 10.1021/jm00226a011 |
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Central nervous system active 5-oxo-1,4,5,6,7,8-hexahydrocinnolines Kuppuswamy Nagarajan, Joy David, and Rashmi K. Shah pp 508 - 511; DOI: 10.1021/jm00226a012 |
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Novel heterocyclic nitrofurfural hydrazones. In vivo antitrypanosomal activity Thomas Novinson, Bharat Bhooshan, Takayuki Okabe, Ganapathi R. Revankar, Roland K. Robins, Keitaro Senga, and H. Robert Wilson pp 512 - 516; DOI: 10.1021/jm00226a013 |
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Synthesis and antimicrobial activity of some novel heterocycles. Azolo-as-triazines Thomas Novinson, Takayuki Okabe, Roland K. Robins, and Thomas R. Matthews pp 517 - 520; DOI: 10.1021/jm00226a014 |
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Circular dichroism and carbon-13 nuclear magnetic resonance spectra of (S)-5-alkyl-5-(2'-pentyl)-2-thiobarbituric acids Frank I. Carroll, Abraham Philip, and Charles G. Moreland pp 521 - 524; DOI: 10.1021/jm00226a015 |
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Syntheses of heterocyclic fused thiazole acetic acids. 2 Stanley C. Bell and Peter H. L. Wei pp 524 - 530; DOI: 10.1021/jm00226a016 |
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(Vinylaryloxy)acetic acids. A new class of diuretic agents. 1. (Diacylvinylaryloxy)acetic acids John B. Bicking, Wilbur J. Holtz, L. Sherman Watson, and Edward J. Cragoe pp 530 - 535; DOI: 10.1021/jm00226a017 |
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Biologically active polycycloalkanes. 2. Antiviral 4-homoisotwistane derivatives Koji Aigami, Yoshiaki Inamoto, Naotake Takaishi, Yoshiaki Fujikura, Akira Takatsuki, and Gakuzo Tamura pp 536 - 540; DOI: 10.1021/jm00226a018 |
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Local anesthetics. 2-Diethylamino-2',6'-acylxylidides Sigmund M. Waraszkiewicz, William O. Foye, H. Jack Adams, and Bertil H. Takman pp 541 - 544; DOI: 10.1021/jm00226a019 |
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(Vinylaryloxy)acetic acids. A new class of diuretic agents. 2. [4-(3-Oxo-1-alkenyl)phenoxy]acetic acids John B. Bicking, Charles M. Robb, L. Sherman Watson, and Edward J. Cragoe pp 544 - 547; DOI: 10.1021/jm00226a020 |
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Synthesis and dopaminergic activity of (+-)-, (+)-, and (-)-2-dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene John D. McDermed, Gerald M. McKenzie, and Harold S. Freeman pp 547 - 549; DOI: 10.1021/jm00226a021 |
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Drugs derived from cannabinoids. 3. Sulfur analogs, thiopyranobenzopyrans and thienobenzopyrans Raj K. Razdan, B. Zitko Terris, G. R. Handrick, Haldean C. Dalzell, H. G. Pars, J. F. Howes, Nicholas P. Plotnikoff, Patrick W. Dodge, Anthony T. Dren, and et al. pp 549 - 551; DOI: 10.1021/jm00226a022 |
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Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs Raj K. Razdan, G. R. Handrick, Haldean C. Dalzell, J. F. Howes, Martin Winn, Nicholas P. Plotnikoff, Patrick W. Dodge, and Anthony T. Dren pp 552 - 554; DOI: 10.1021/jm00226a023 |
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Synthesis and biological activities of some N4-substituted 4-aminopyrazolo[3,4-d]pyrimidines C. I. Hong, N. C. De, G. L. Tritsch, and G. B. Chheda pp 555 - 558; DOI: 10.1021/jm00226a024 |
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Catechol O-methyltransferase. 8. Structure-activity relationships for inhibition by 8-hydroxyquinolines Ronald T. Borchardt, Dhiren R. Thakker, Victor D. Warner, Dale B. Mirth, and Jayant N. Sane pp 558 - 560; DOI: 10.1021/jm00226a025 |
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Bridged aminotetralins. 4. Resolution of potent analgesics of the bridged aminotetralin type Meier E. Freed, John R. Potoski, George L. Conklin, and Stanley C. Bell pp 560 - 562; DOI: 10.1021/jm00226a026 |
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3-Cyanocephems and carbon-13 heterocyclic-substituted cephems via 1,3-dipolar cycloadditions John L. Fahey, Raymond A. Firestone, and B. G. Christensen pp 562 - 565; DOI: 10.1021/jm00226a027 |
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Book Reviews pp 565 - 568; DOI: 10.1021/jm00226a600 |
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Correction - Ergoline Congeners as Potential Inhibitors of Prolactin Release. 2. D. B. Rusterholz, C. F .Barfknecht, and J. A. Clemens pp 568 - 568; DOI: 10.1021/jm00226a601 |
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Application of SCAP to drug design. 1. Prediction of octanol-water partition coefficients using solvent-dependent conformational analyses Anton J. Hopfinger and Robert D. Battershell pp 569 - 573; DOI: 10.1021/jm00227a001 |
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Molecular connectivity. 6. Examination of the parabolic relationship between molecular connectivity and biological activity Wallace J. Murray, Lemont B. Kier, and Lowell H. Hall pp 573 - 578; DOI: 10.1021/jm00227a002 |
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Quantitative structure-activity relationships. 1. The modified Free-Wilson approach Hugo Kubinyi and Ott H. Kehrhahn pp 578 - 586; DOI: 10.1021/jm00227a003 |
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Quantitative structure-activity relationships. 2. A mixed approach, based on Hansch and Free-Wilson analysis Hugo Kubinyi pp 587 - 600; DOI: 10.1021/jm00227a004 |
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Quantitative structure-activity studies on monoamine oxidase inhibitors Carl Lynn Johnson pp 600 - 605; DOI: 10.1021/jm00227a005 |
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Inhibition of dihydrofolate reductase. Structure-activity correlations of quinazolines James Y. Fukunaga, Corwin Hansch, and Edward E. Steller pp 605 - 611; DOI: 10.1021/jm00227a006 |
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Dependence of hydrophobicity of apolar molecules on their molecular volume A. Leo, Corwin Hansch, and Priscilla Y. C. Jow pp 611 - 615; DOI: 10.1021/jm00227a007 |
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Direct measurement of octanol-water partition coefficients by high-pressure liquid chromatography Margaret S. Mirrlees, Stuart J Moulton, Christopher T. Murphy, and Peter J. Taylor pp 615 - 619; DOI: 10.1021/jm00227a008 |
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Use of high-pressure liquid chromatography for quantitative structure-activity relationship studies of sulfonamides and barbiturates Doug Henry, John H. Block, John L. Anderson, and Garnet R. Carlson pp 619 - 626; DOI: 10.1021/jm00227a009 |
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Adrenergic sulfonanilides. 4. Centrally active .beta.-adrenergic agonists D. L. Temple, W. T. Comer, H. C. Ferguson, and L. E. Allen pp 626 - 633; DOI: 10.1021/jm00227a010 |
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Novel bis(benzamidino) compounds with an aromatic central link. Inhibitors of thrombin, pancreatic kallikrein, trypsin, and complement J. D. Geratz, M. C. F. Cheng, and R. R. Tidwell pp 634 - 639; DOI: 10.1021/jm00227a011 |
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Synthesis and anticancer activity of 5-diethylaminomethyl derivatives and nitrogen mustards of uracil and 2-thiouracils Silvio Fabrissin, Marilena De Nardo, Carlo Nisi, Ersilia Dolfini, Giuseppe Franchi, and Luciano Morasca pp 639 - 642; DOI: 10.1021/jm00227a012 |
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Synthesis and biological studies of 3-(.beta.-D-ribofuranosyl)-2,3-dihydro-6H-1,3-oxazine-2,6-dione, a new pyrimidine nucleoside analog related to uridine Tek-Ling Chwang, William F. Wood, J. Rodney Parkhurst, Stephen Nesnow, Peter V. Danenberg, and Charles Heidelberger pp 643 - 647; DOI: 10.1021/jm00227a013 |
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Metabolic formation and synthesis of 1-(3-chlorophenyl)-2-(4-hydroxyphenyl)-1-methyl-2-(2-pyridine)ethanol. A potential hypocholesteremic agent J. E. Sinsheimer, E. Van den Eeckhout, L. E. Hewitt, Y. Kido, D. R. Wade, D. W. Hansen, J. C. Drach, and J. H. Burckhalter pp 647 - 650; DOI: 10.1021/jm00227a014 |
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Cellular pharmacodynamics of several anthracycline antibiotics Nicholas R. Bachur, Malcolm Steele, W. Delano Meriwether, and Robert C. Hildebrand pp 651 - 654; DOI: 10.1021/jm00227a015 |
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Reactions of 2-acyloxyisobutyryl halides with nucleosides. 6. Synthesis and biological evaluation of some 3'-acyl derivatives of 2,2'-anhydro-1-(.beta.-D-arabinofuranosyl)cytosine hydrochloride Ernest K. Hamamura, Miroslav Prystasz, Julien P. H. Verheyden, John G. Moffatt, Kenji Yamaguchi, Naomi Uchida, Kosaburo Sato, Akio Nomura, Osamu Shiratori, and et al. pp 654 - 662; DOI: 10.1021/jm00227a016 |
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Reactions of 2-acyloxyisobutyryl halides with nucleosides. 7. Synthesis and biological evaluation of some 2,2'-anhydro-1-(3',5'-di-O-acyl-.beta.-D-arabinofuranosyl)cytosine hydrochlorides Ernest K. Hamamura, Miroslav Prystasz, Julien P. H. Verheyden, John G. Moffatt, Kenji Yamaguchi, Naomi Uchida, Kosaburo Sato, Akio Nomura, Osamu Shiratori, and et al. pp 663 - 667; DOI: 10.1021/jm00227a017 |
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Reactions of 2-acyloxyisobutyryl halides with nucleosides. 8. Synthesis and biological evaluation of some 3'-acyl and 3',5'-diacyl derivatives of 1-.beta.-D-arabinofuranosylcytosine Ernest K. Hamamura, Miroslav Prystasz, Julien P. H. Verheyden, John G. Moffatt, Kenji Yamaguchi, Naomi Uchida, Kosaburo Sato, Akio Nomura, Osamu Shiratori, and et al. pp 667 - 674; DOI: 10.1021/jm00227a018 |
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Experiments on the synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues Tsutomu Sugasawa, Tatsuo Toyoda, Naomi Uchida, and Kenji Yamaguchi pp 675 - 679; DOI: 10.1021/jm00227a019 |
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Solid-phase synthesis and drug glucuronides by immobilized glucuronosyltransferase Catherine Fenselau, Sharon Pallante, and Indu Parikh pp 679 - 683; DOI: 10.1021/jm00227a020 |
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Analogues of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis of analogues with modifications at the 5'-thioether linkage Chi-Deu Chang and James K. Coward pp 684 - 691; DOI: 10.1021/jm00227a021 |
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Conformations and "nicotinic" activities of cyclic analogues of choline aryl ether E. R. Clark, I. E. Hughes, and C. F. C. Smith pp 692 - 695; DOI: 10.1021/jm00227a022 |
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Sulfamylurea hypoglycemic agents. 6. High-potency derivatives Reinhard Sarges, Donald E. Kuhla, Hans E. Wiedermann, and Dale A. Mayhew pp 695 - 709; DOI: 10.1021/jm00227a023 |
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Synthesis and biological evaluation of substituted 2,2'-oxybis(propionic acid) derivatives and related compounds Gregory B. Bennett, William J. Houlihan, Robert B. Mason, and Robert G. Engstrom pp 709 - 714; DOI: 10.1021/jm00227a024 |
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Synthesis and biological activity of a series of 1-aryl-3-pyrazolidinones Gregory B. Bennett, William J. Houlihan, Robert B. Mason, and J. B. Roach pp 715 - 717; DOI: 10.1021/jm00227a025 |
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Diester derivatives as apomorphine prodrugs Robert J. Borgman, Ross J. Baldessarini, and Kenneth G. Walton pp 717 - 719; DOI: 10.1021/jm00227a026 |
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Drugs derived from cannabinoids. 6. Synthesis of cyclic analogues of dimethylheptylpyran Raj K. Razdan and Haldean C. Dalzell pp 719 - 721; DOI: 10.1021/jm00227a027 |
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Preparation of 16.alpha.-alkoxy and 16.alpha.-acyloxy derivatives of 21-chloro-17-acyloxycorticosteroids and determination of their vasoconstrictor activities in humans Christopher M. Cimarusti, Sam T. Chao, and Leo J. Brannick pp 721 - 723; DOI: 10.1021/jm00227a028 |
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Antimalarial activity of some novel derivatives of 2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine (Pyrimethamine) Richard W. A. Rees, Sie Yearl Chai, Michael W. Winkley, and Peter B. Russell pp 723 - 725; DOI: 10.1021/jm00227a029 |
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Conformationally rigid amphetamine analogs as inhibitors of monoamine uptake by brain synaptosomes Jouko Tuomisto, Leena Tuomisto, and Thomas L. Pazdernik pp 725 - 727; DOI: 10.1021/jm00227a030 |
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Partition coefficients and surface areas of some alkylbenzenes S. H. Yalkowsky and S. C. Valvani pp 727 - 728; DOI: 10.1021/jm00227a031 |
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Metabolic and photochemical hydroxylation of 5-nitro-2-furancarboxaldehyde derivatives Joanne Olivard, Gordon M. Rose, George M. Klein, and James P. Heotis pp 729 - 731; DOI: 10.1021/jm00227a032 |
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Stereocontrolled glycosidation of daunomycinone. Synthesis and biological evaluation of 6-hydroxy-L-arabino analogues of antitumor anthracyclines F. Arcamone, A. Bargiotti, G. Cassinelli, S. Redaelli, S. Hanessian, A. Di Marco, A. M. Casazza, T. Dasdia, A. Necco, and et al. pp 733 - 734; DOI: 10.1021/jm00227a033 |
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Antidepressant and Anticonvulsant Activity of 1-(5-Phenyl-4-oxo-2-oxazolin-2-yl)-4-substituted Piperazines Cheuk-Man Lee, and Nicholas P. Plotnikoff pp 731 - 733; DOI: 10.1021/jm00227a600 |
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Book Reviews pp 735 - 738; DOI: 10.1021/jm00227a601 |
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Pattern recognition. Classification of therapeutic agents according to pharmacophores Arthur Cammarata and Govind K. Menon pp 739 - 748; DOI: 10.1021/jm00228a001 |
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Quantitative structure-activity relations among steroids. Investigations of the use of steric parameters Robert A. Coburn and Alan J. Solo pp 748 - 754; DOI: 10.1021/jm00228a002 |
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Semisynthetic cephalosporins. Synthesis and structure-activity relations of 7-sulfonylacetamido-3-cephem-4-carboxylic acids R. M. DeMarinis, J. R. E. Hoover, L. L. Lam, J. V. Uri, J. R. Guarini, L. Phillips, P. Actor, and J. A. Weisbach pp 754 - 759; DOI: 10.1021/jm00228a003 |
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Synthesis and structure-toxicity relationships of three new stable analogues of acetyl-seco-hemicholinium-3 Vernon B. Haarstad, Floyd R. Domer, David M. Chihal, Arvind B. Rege, and H. Cecil Charles pp 760 - 763; DOI: 10.1021/jm00228a004 |
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Synthesis and biological evaluation of fragmented derivatives of tetrahydroisoquinolines. 3. Trimetoquinol studies Duane D. Miller, Peter F. Kador, R. Venkatraman, and Dennis R. Feller pp 763 - 766; DOI: 10.1021/jm00228a005 |
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Synthesis of actinomycin and analogs. 12. Synthesis and some properties and antitumor effects of the actinomycin lactam analog, [di-(1'-L-.alpha.,.beta.-diaminopropionic acid)]actinomycin D Stanley Moore, Ravindra P. Patel, Eric Atherton, Michio Kondo, Johannes Meienhofer, Lea Blau, Robert Bittman, and Randall K. Johnson pp 766 - 772; DOI: 10.1021/jm00228a006 |
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Potential antitumor agents. 17. 9-Anilino-10-methylacridinium salts Bruce F. Cain, Graham J. Atwell, and William A. Denny pp 772 - 777; DOI: 10.1021/jm00228a007 |
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1-Halobenzyl-1H-indazole-3-carboxylic acids. A new class of antispermatogenic agents Giorgio Corsi, Giuseppe Palazzo, Claudio Germani, Patrizio Scorza Barcellona, and Bruno Silvestrini pp 778 - 783; DOI: 10.1021/jm00228a008 |
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(Vinylaryloxy)acetic acids. A new class of diuretic agents. 3. [(2-Nitro-1-alkenyl)aryloxy]acetic acids Everett M. Schultz, John B. Bicking, Albert A. Deana, Norman P. Gould, Terence P. Strobaugh, L. Sherman Watson, and Edward J. Cragoe pp 783 - 787; DOI: 10.1021/jm00228a009 |
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Cycloalkanoindoles. 1. Syntheses and antiinflammatory actions of some acidic tetrahydrocarbazoles, cyclopentindoles, and cycloheptindoles Andre A. Asselin, Leslie G. Humber, Thomas A. Dobson, Jacqueline Komlossy, and Rene R. Martel pp 787 - 792; DOI: 10.1021/jm00228a010 |
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Cycloalkanoindoles. 2. 1-Alkyl-1,2,3,4-tetrahydrocarbazole-1-ethanamines and related compounds. Potential antidepressants Andre A. Asselin, Leslie G. Humber, Jacqueline Komlossy, and Marie P. Charest pp 792 - 797; DOI: 10.1021/jm00228a011 |
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Biologically oriented organic sulfur chemistry. 14. Antiinflammatory properties of some aryl sulfides, sulfoxides, and sulfones Lawrence H. Brannigan, Ruth B. Hodge, and Lamar Field pp 798 - 802; DOI: 10.1021/jm00228a012 |
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10-Hydroxy-4-methyl-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine derivatives (homobenzomorphans) as analgesics Shunsaku Shiotani, Tadashi Kometani, Kemmotsu Mitsuhashi, Tsutomu Nozawa, Akira Kurobe, and Osamu Futsukaichi pp 803 - 806; DOI: 10.1021/jm00228a013 |
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Synthesis of aziridinyallylaminophosphine oxides and sulfides as potential adjuvant cancer chemotherapeutic agents K. C. Tsou, D. Bender, N. Santora, L. David, S. Damle, and A. B. Borkovec pp 806 - 810; DOI: 10.1021/jm00228a014 |
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Imidazo[1,2-c]pyrimidine nucleosides. Synthesis and biological evaluation of certain 1-(.beta.-D-arabinofuranosyl)imidazo[1,2-c]pyrimidines David G. Bartholomew, John H. Huffman, Thomas R. Matthews, Roland K. Robins, and Ganapathi R. Revankar pp 814 - 816; DOI: 10.1021/jm00228a015 |
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Benzodipyran derivatives with antiallergic activity John R. Bantick, Hugh Cairns, Albert Chambers, Richard Hazard, John King, Thomas B. Lee, and Robert Minshull pp 817 - 821; DOI: 10.1021/jm00228a016 |
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Oxytocin analogues with combined high smooth muscle and negligible antidiuretic activities. Investigation of position 7 in neurohypophyseal hormones Roderich Walter, Clark W. Smith, J. Roy, and Alice Formento pp 822 - 825; DOI: 10.1021/jm00228a017 |
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Folate analogues altered in the C9-N10 bridge region. 10-Oxafolic acid and 10-oxaaminopterin M. G. Nair and Patricia T. Campbell pp 825 - 829; DOI: 10.1021/jm00228a018 |
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Antineoplastic and biochemical properties of arylsulfonylhydrazones of 2-formylpyridine N-oxide Alan C. Sartorelli, Krishna C. Agrawal, Barbara A. Booth, James Pittman, David G. Bartholomew, and Arthur D. Broom pp 830 - 833; DOI: 10.1021/jm00228a019 |
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Esters of N-tert-butylarterenol. Long-acting new bronchodilators with reduced cardiac effects Benjamin F. Tullar, Hiroaki Minatoya, and Roman R. Lorenz pp 834 - 838; DOI: 10.1021/jm00228a020 |
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Synthesis of 1- and 2-substituted indazoles as anthelmintic agents William D. Kingsbury, Robert J. Gyurik, Vassilios J. Theodorides, Roger C. Parish, and Gregory Gallagher pp 839 - 840; DOI: 10.1021/jm00228a021 |
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Synthesis of 1-(4-thio-.beta.-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide Michael V. Pickering, Joseph T. Witkowski, and Roland K. Robins pp 841 - 842; DOI: 10.1021/jm00228a022 |
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Synthesis and some pharmacological properties of deamino[4-threonine,8-D-arginine]vasopressin and deamino[8-D-arginine]vasopressin, highly potent and specific antidiuretic peptides, and [8-D-arginine]vasopressin and deamino-arginine-vasopressin Maurice Manning, Lajos Balaspiri, Jacqueline Moehring, Jaya Haldar, and Wilbur H. Sawyer pp 842 - 845; DOI: 10.1021/jm00228a023 |
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Antimalarials. 3. 1,2,4-Triazines Louis C. March, Gurdip S. Bajwa, Jessie Lee, Khizar Wasti, and Madeleine M. Joullie pp 845 - 848; DOI: 10.1021/jm00228a024 |
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Effect of chain length on critical micelle formation and protein binding of quaternary ammonium compounds Eric J. Lien and John H. Perrin pp 849 - 850; DOI: 10.1021/jm00228a025 |
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A potential amphetamine antagonist, adamantanamine derivative of fluphenazine Beng T. Ho, Leo F. Englert, and Mary L. McKenna pp 850 - 852; DOI: 10.1021/jm00228a026 |
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2-Azabicyclo[2.2.2]octane analogues of the prodine analgetics C. Randall Clark, John M. Holbrook, and Ronald F. Borne pp 852 - 854; DOI: 10.1021/jm00228a027 |
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Biological activity of carbon-terminal partial sequences of substance P Ross W. Bury and Maurice L. Mashford pp 854 - 856; DOI: 10.1021/jm00228a028 |
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Stereospecific interaction of the quaternized opiate, N-methyllevorphanol, with opiate receptors Kent E. Opheim and Brian M. Cox pp 857 - 858; DOI: 10.1021/jm00228a029 |
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Synthesis and Properties of 2-S-[2'-(N,N-Dialkylamino)ethyl]thio-1,3,2-dioxaphosphorinane 2-Oxide and of the Corresponding Quaternary Derivatives as Potential Nontoxic Antiglaucoma Agents Gavriel Amitai, Yacov Ashani, Yona Grunfeld, Asher Kalir, and Sasson Cohen pp 810 - 813; DOI: 10.1021/jm00228a600 |
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Book Reviews pp 858 - 862; DOI: 10.1021/jm00228a601 |
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Quantum chemical studies of methadone Gilda H. Loew, Donald S. Berkowitz, and Richard C. Newth pp 863 - 869; DOI: 10.1021/jm00229a001 |
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Structure-activity studies on sulfamate sweeteners G. Anthony Benson and William J. Spillane pp 869 - 872; DOI: 10.1021/jm00229a002 |
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Synthesis and some pharmacological properties of oxytocin analogues having L-thiazolidine-4-carboxylic acid in position 7 James D. Rosamond and Martha F. Ferger pp 873 - 876; DOI: 10.1021/jm00229a003 |
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Synthesis and antihypertensive activity of some thienylethanolamines Jehan F. Bagli, Walter D. Mackay, Eckhardt Ferdinandi, Mitchell N. Cayen, Ivan Vavra, Thomas Pugsley, and Wilbur Lippmann pp 876 - 882; DOI: 10.1021/jm00229a004 |
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Tetramethoxydibenzoquinolizinium salts. Preparation and antileukemic activity of some positional and structural isomers of coralyne Robert K. Y. Zee-Cheng and C. C. Cheng pp 882 - 886; DOI: 10.1021/jm00229a005 |
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Synthesis, antimalarial activity, and phototoxicity of some benzo[h]quinoline-4-methanols Kenner C. Rice, Betty J. Boone, Alan B. Rubin, and T. J. Rauls pp 887 - 892; DOI: 10.1021/jm00229a006 |
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Oxindole-3-spiropyrrolidines and -piperidines. Synthesis and local anesthetic activity Milton J. Kornet and Alan P. Thio pp 892 - 898; DOI: 10.1021/jm00229a007 |
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Synthesis of new cyclic nucleotides and their differential stimulatory effects on thyroid function in mice Georges Cehovic, Monika Bayer, and Nguyen Ba Giao pp 899 - 903; DOI: 10.1021/jm00229a008 |
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Synthetic inhibitors of Escherichia coli, calf thymus, and Ehrlich ascites tumor thymidylate synthetase Arieh Kampf, Roxane L. Barfknecht, Phyllis J. Shaffer, Shigemasa Osaki, and Mathias P. Mertes pp 903 - 908; DOI: 10.1021/jm00229a009 |
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Synthesis of 5-substituted 2'-deoxyuridines Arieh Kampf, Conrad J. Pillar, Warren J. Woodford, and Mathias P. Mertes pp 909 - 915; DOI: 10.1021/jm00229a010 |
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Synthesis and biological activities of 5-trifluoromethyl-5'-azido-2',5'-dideoxyuridine and 5-trifluoromethyl-5'-amino-2',5'-dideoxyuridine Tai-Shun Lin, Caroline Chai, and William H. Prusoff pp 915 - 918; DOI: 10.1021/jm00229a011 |
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Alkyl streptozotocin analogues with improved biological activities Morio Iwasaki, Masaki Ueno, Kenji Ninomiya, Junzo Sekine, Yasuhiro Nagamatsu, and Goro Kimura pp 918 - 923; DOI: 10.1021/jm00229a012 |
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Potential histamine H2-receptor antagonists. 3. Methylhistamines Graham J. Durant, John C. Emmett, C. Robin Ganellin, Anthony M. Roe, and R. Antony Slater pp 923 - 928; DOI: 10.1021/jm00229a013 |
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Quaternary pilocarpine derivatives as potential acetylcholine antagonists. 2. Alterations in the lactone and imidazole moieties Avraham A. Ben-Bassat, David Lavie, Habib Edery, and Gila Porath pp 928 - 933; DOI: 10.1021/jm00229a014 |
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Vinyl ethers of choline and congeners Joseph G. Cannon, Aleem Gangjee, John Paul Long, and Albert John Allen pp 934 - 937; DOI: 10.1021/jm00229a015 |
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Analogues of luteinizing hormone releasing factor modified at positions 2, 6, and 10 Nicholas C. Ling, Jean E. Rivier, Michael W. Monahan, and Wylie W. Vale pp 937 - 941; DOI: 10.1021/jm00229a016 |
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6,11-Dihydro-11-oxodibenz[b,e]oxepinacetic acids with potent antiinflammatory activity Katsujiro Ueno, Shiro Kubo, Hiroaki Tagawa, Toshiyuki Yoshioka, Wataru Tsukada, Masao Tsubokawa, Hiroshi Kojima, and Akira Kasahara pp 941 - 946; DOI: 10.1021/jm00229a017 |
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Hypolipidemic alkoxybenzoic acids Vern G. DeVries, Daniel B. Moran, George R. Allen, and Stephen J. Riggi pp 946 - 957; DOI: 10.1021/jm00229a018 |
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Chemistry of nitrosoureas. Decomposition of deuterated 1,3-bis(2-chloroethyl)-1-nitrosourea Robert B. Brundrett, J. Wayne Cowens, Michael Colvin, and Ian Jardine pp 958 - 961; DOI: 10.1021/jm00229a019 |
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Tissue distribution of technetium-99m and carbon-14 labeled N-(2,6-dimethylphenylcarbamoylmethyl)iminodiacetic acid Patrick S. Callery, William C. Faith, Michael D. Loberg, Anna T. Fields, Elizabeth B. Harvey, and Malcolm D. Cooper pp 962 - 964; DOI: 10.1021/jm00229a020 |
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Preliminary biological studies of certain amino acid analogues C. J. Abshire and M. Ostiguy pp 965 - 966; DOI: 10.1021/jm00229a021 |
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Adamantane and protoadamantanealkanamines as potential anti-Parkinson agents. 10 Jiban K. Chakrabarti, Terrence M. Hotten, Susan Sutton, and David E. Tupper pp 967 - 969; DOI: 10.1021/jm00229a022 |
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Potential antitumor agents. 13. 4-Methyl-5-amino-1-formylisoquinoline thiosemicarbazone Krishna C. Agrawal, Paul D. Mooney, and Alan C. Sartorelli pp 970 - 972; DOI: 10.1021/jm00229a023 |
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(Vinylaryloxy)acetic acids. A new class of diuretic agents. 4. Various [(2-substituted and 2,2-disubstituted vinyl)aryloxy]acetic acids Otto W. Woltersdorf, Charles M. Robb, John B. Bicking, L. Sherman Watson, and Edward J. Cragoe pp 972 - 975; DOI: 10.1021/jm00229a024 |
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Synthesis and antimineralocorticoid activities of some 7.alpha.-cyano and 7.alpha.-alkoxycarbonylamino steroidal spirolactones Richard M. Weier and Lorenz M. Hofmann pp 975 - 977; DOI: 10.1021/jm00229a025 |
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On the use of Fibonacci searches in structure-activity studies Stanley N. Deming pp 977 - 978; DOI: 10.1021/jm00229a026 |
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Antimalarials. 9. Methylthio- and methylsulfonyl-substituted 9-phenanthrenemethanols A. Markovac and M. P. LaMontagne pp 978 - 982; DOI: 10.1021/jm00229a027 |
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A new class of diuretics with the 1,4-dioxino[2,3-g]quinolone structure J. Van Dijk, J. Hartog, and T. A. C. Boschman pp 982 - 983; DOI: 10.1021/jm00229a028 |
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Book Reviews pp 984 - 986; DOI: 10.1021/jm00229a600 |
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Centrally acting emetics. 10. Rigid dopamine congeners derived from octahydrobenzo[f]quinoline Joseph G. Cannon, Gerard J. Hatheway, John Paul Long, and Fouad M. Sharabi pp 987 - 993; DOI: 10.1021/jm00230a001 |
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Synthesis and biological properties of some spin-labeled 9-aminoacridines Birandra K. Sinha, Richard L. Cysyk, David B. Millar, and Colin F. Chignell pp 994 - 998; DOI: 10.1021/jm00230a002 |
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Synthesis and biological properties of 4-amino- and 4-bromo-4-norpyridoxol. New approaches for the modification of the 4 position of vitamin B6 W. Korytnyk, A. C. Ghosh, P. G. G. Potti, and S. C. Srivastava pp 999 - 1002; DOI: 10.1021/jm00230a003 |
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Cysteine derivatives with reactive groups as potential antitumor agents B. Paul and W. Korytnyk pp 1002 - 1007; DOI: 10.1021/jm00230a004 |
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Synthesis and biological evaluation of .omega.-homologues of prostaglandin E1 Esam Z. Dajani, Leonard F. Rozek, John H. Sanner, and Masateru Miyano pp 1007 - 1010; DOI: 10.1021/jm00230a005 |
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Tyrosylated analogues of somatostatin Jean E. Rivier, Marvin R. Brown, and Wylie W. Vale pp 1010 - 1013; DOI: 10.1021/jm00230a006 |
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Nucleic acids. 16. Orally active derivatives of ara-cytidine W. J. Wechter, D. T. Gish, M. E. Greig, G. D. Gray, T. E. Moxley, S. L. Kuentzel, L. G. Gray, A. J. Gibbons, R. L. Griffin, and G. L. Neil pp 1013 - 1017; DOI: 10.1021/jm00230a007 |
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Synthesis of tetrazole ribonucleosides and their evaluation as antiviral agents. 2. 5-Amino-1-(.beta.-D-ribofuranosyl)-1H-tetrazole and 5-amino-2-(.beta.-D-ribofuranosyl)-2H-tetrazole Mohindar S. Poonian, Eugene F. Nowoswiat, John F. Blount, and Michael J. Kramer pp 1017 - 1020; DOI: 10.1021/jm00230a008 |
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Synthesis and antiviral and antimicrobial activity of certain 1-.beta.-D-ribofuranosyl-4,5-disubstituted imidazoles Prem C. Srivastava, David G. Streeter, Thomas R. Matthews, Lois B. Allen, Robert W. Sidwell, and Roland K. Robins pp 1020 - 1026; DOI: 10.1021/jm00230a009 |
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Synthesis and anti-DNA virus activity of the 5'-monophosphate and the cyclic 3',5'-monophosphate of 9-(.beta.-D-xylofuranosyl)guanine Ganapathi R. Revankar, John H. Huffman, Robert W. Sidwell, Richard L. Tolman, Roland K. Robins, and Lois B. Allen pp 1026 - 1028; DOI: 10.1021/jm00230a010 |
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Design of substrate-site-directed irreversible inhibitors of adenosine 5'-phosphate aminohydrolase. Effect of substrate substituents on affinity for the substrate site Alexander Hampton, Takuma Sasaki, Florian Perini, Lewis A. Slotin, and Francis Kappler pp 1029 - 1033; DOI: 10.1021/jm00230a011 |
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Theoretical model-based equations for the linear free energy relations of the biological activity of ionizable substances. 1. Equilibrium-controlled potency Yvonne C. Martin and James J. Hackbarth pp 1033 - 1039; DOI: 10.1021/jm00230a012 |
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Quantitative structure-activity relationships. 3. A comparison of different Free-Wilson models Hugo Kubinyi and Ott H. Kehrhahn pp 1040 - 1049; DOI: 10.1021/jm00230a013 |
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Clonidine and related analogues. Quantitative correlations Bruno Rouot, Gerard Leclerc, Camille G. Wermuth, Francois Miesch, and Jean Schwartz pp 1049 - 1054; DOI: 10.1021/jm00230a014 |
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(-)-3-Isothujone, a small nonnitrogenous molecule with antinociceptive activity in mice Kenner C. Rice and Raymond S. Wilson pp 1054 - 1057; DOI: 10.1021/jm00230a015 |
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Synthesis and pharmacology of novel anxiolytic agents derived from 2-[(dialkylamino)methyl-4H-triazol-4-yl]benzophenones and related heterocyclic benzophenones Martin Gall, J. B. Hester, A. D. Rudzik, and Robert A. Lahti pp 1057 - 1064; DOI: 10.1021/jm00230a016 |
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Conversion of N-alkylaminobenzophenones to benzodiazepines in vivo Robert A. Lahti and Martin Gall pp 1064 - 1067; DOI: 10.1021/jm00230a017 |
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Synthesis of 3-iodo-L-thyronine and its iodinated derivatives Paul Block pp 1067 - 1069; DOI: 10.1021/jm00230a018 |
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Antifungal activity of 4-substituted crotonic acid esters Herman Gershon, Larry Shanks, and Daniel E. Gawiak pp 1069 - 1072; DOI: 10.1021/jm00230a019 |
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Synthesis and antimicrobial evaluation of substituted 5,6-dihydro-5-nitrouracils Robert A. Long, Thomas R. Matthews, and Roland K. Robins pp 1072 - 1074; DOI: 10.1021/jm00230a020 |
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Optical isomers of 2-(2-ethoxyphenoxymethyl)tetrahydro-1,4-oxazine (viloxazine) and related compounds Ralph Howe, Thomas Leigh, Balbir S. Rao, and Alexander H. Todd pp 1074 - 1076; DOI: 10.1021/jm00230a021 |
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Book Reviews pp 1077 - 1078; DOI: 10.1021/jm00230a600 |
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Irreversible enzyme inhibitors. Inhibitors of guinea pig complement derived by quaternization of substituted pyridines with benzyl halides Michael H. Doll and B. R. Baker pp 1079 - 1088; DOI: 10.1021/jm00231a001 |
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Structure-activity relationships in immunochemistry. 4. Inhibition of complement by benzylpyridinium ions. On the predictive value of correlation equations Corwin Hansch, Masafumi Yoshimoto, and Michael H. Doll pp 1089 - 1093; DOI: 10.1021/jm00231a002 |
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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 4. Further modifications of the amino acid and base portions of S-adenosyl-L-homocysteine R. T. Borchardt, J. A. Huber, and Yih Shiong Wu pp 1094 - 1099; DOI: 10.1021/jm00231a003 |
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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 5. Role of the asymmetric sulfonium pole in the enzymic binding of S-adenosyl-L-methionine R. T. Borchardt and Yih Shiong Wu pp 1099 - 1103; DOI: 10.1021/jm00231a004 |
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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 6. Structural modifications of S-adenosylmethionine R. T. Borchardt, Yih Shiong Wu, J. A. Huber, and A. F. Wycpalek pp 1104 - 1110; DOI: 10.1021/jm00231a005 |
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Reduced 8-aminoquinoline analogues as potential antimalarial agents F. I. Carroll, J. T. Blackwell, Abraham Philip, and Charles E. Twine pp 1111 - 1119; DOI: 10.1021/jm00231a006 |
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.beta.-Adrenergic blocking agents. 13. (3-Amino-2-hydroxypropoxy)benzamides L. H. Smith pp 1119 - 1123; DOI: 10.1021/jm00231a007 |
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Potential antitumor agents. 19. Multiply substituted 4'-(9-acridinylamino)methanesulfonanilides Bruce F. Cain and Graham J. Atwell pp 1124 - 1129; DOI: 10.1021/jm00231a008 |
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Structural requirements for biological activity among antileukemic glaucarubolone ester quassinoids S. Morris Kupchan, John A. Lacadie, Gary A. Howie, and Barry R. Sickles pp 1130 - 1133; DOI: 10.1021/jm00231a009 |
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Phosphorus-nitrogen compounds. 20. Thiophosphorus hydrazones L. A. Cates, Y. M. Cho, L. K. Smith, L. Williams, and T. L. Lemke pp 1133 - 1137; DOI: 10.1021/jm00231a010 |
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Sympathomimetic amines having a carbostyril nucleus Shiro Yoshizaki, Kaoru Tanimura, Shigeharu Tamada, Youichi Yabuuchi, and Kazuyuki Nakagawa pp 1138 - 1142; DOI: 10.1021/jm00231a011 |
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Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 7. Bisalkamine esters of 9-oxoxanthene-2,7-dicarboxylic acid, 3,6-bis-basic ethers of xanthen-9-one, and 2,7-bis(aminoacyl)xanthen-9-ones, -xanthenes, and -thioxanthenes Albert A. Carr, Joyce F. Grunwell, Arthur D. Sill, Donald R. Meyer, F. William Sweet, B. Joseph Scheve, J. Martin Grisar, Robert W. Fleming, and Gerald D. Mayer pp 1142 - 1148; DOI: 10.1021/jm00231a012 |
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Synthesis and antimycotic properties of 1-(2-alkyl-2-phenylethyl)-1H-imidazoles J. Heeres, L. J. J. Backx, and J. M. Van Cutsem pp 1148 - 1155; DOI: 10.1021/jm00231a013 |
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Stereochemical studies on medicinal agents. 20. Absolute configuration and analgetic potency of .alpha.-promedol enantiomers. The role of the C-4 chiral center in conferring stereoselectivity in axial- and equatorial-phenylprodine congeners David S. Fries and Philip S. Portoghese pp 1155 - 1158; DOI: 10.1021/jm00231a014 |
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Benzo[g]quinolines. 3. Influence of carbon-5 substituents on narcotic antagonist and antiwrithing activities of derivatives of cis-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-7-ol William F. Michne pp 1159 - 1161; DOI: 10.1021/jm00231a015 |
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Synthesis and anticonvulsant properties of 1-(10-cyano- and -10-bromo-5H-dibenzo[a,d]cyclohepten-5-yl)-4-[(arylmethylene)amino]piperazines Charles R. Ellefson and John W. Cusic pp 1161 - 1164; DOI: 10.1021/jm00231a016 |
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9-Nor-9-hydroxyhexahydrocannabinols. Synthesis, some behavioral and analgesic properties, and comparison with the tetrahydrocannabinols Raymond S. Wilson, Everette L. May, Billy R. Martin, and William L. Dewey pp 1165 - 1167; DOI: 10.1021/jm00231a017 |
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Metabolic N-demethylation of nicotine. Trapping of a reactive iminium species with cyanide ion Nguyen Trong Lang, Larry D. Gruenke, and Neal Castagnoli Jr. pp 1168 - 1169; DOI: 10.1021/jm00231a018 |
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Book Reviews pp 1169 - 1170; DOI: 10.1021/jm00231a600 |
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A practical synthesis of codeine from dihydrothebainone Dwight D. Weller and Henry Rapoport pp 1171 - 1175; DOI: 10.1021/jm00232a001 |
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Conversion of thebaine to codeine Randy B. Barber and Henry Rapoport pp 1175 - 1180; DOI: 10.1021/jm00232a002 |
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Modification of the 5' position of purine nucleosides. 1. Synthesis and biological properties of alkyl adenosine-5'-carboxylates Raj N. Prasad, Anthony Fung, Karin Tietje, Herman Stein, and Harold D. Brondyk pp 1180 - 1186; DOI: 10.1021/jm00232a003 |
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Analogs of 8-azaguanosine Robert D. Elliott and John A. Montgomery pp 1186 - 1191; DOI: 10.1021/jm00232a004 |
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Inhibitors of tRNA methyltransferases. S-Adenosylsulfonium salts Margaret E. Gnegy and Frederick J. Lotspeich pp 1191 - 1195; DOI: 10.1021/jm00232a005 |
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(2-Piperidine)- and (2-pyrrolidine)ethanones and -ethanols as inhibitors of blood platelets aggregation J. Martin Grisar, George P. Claxton, Kenneth T. Stewart, Robert D. MacKenzie, and Takashi Kariya pp 1195 - 1201; DOI: 10.1021/jm00232a006 |
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Catechol O-methyltransferase. 9. Mechanism of inactivation by 6-hydroxydopamine R. T. Borchardt, J. R. Reid, D. R. Thakker, Y. O. Liang, R. W. Wightman, and R. N. Adams pp 1201 - 1209; DOI: 10.1021/jm00232a007 |
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Potential antitumor agents. 14. 4-Substituted 2-formylpyridine thiosemicarbazones Krishna C. Agrawal, Barbara A. Booth, Suzanne M. DeNuzzo, and Alan C. Sartorelli pp 1209 - 1214; DOI: 10.1021/jm00232a008 |
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Synthesis and antilipidemic properties of cis-7-chloro-3a,8b-dihydro-3a-methylfuro[3,4-b]benzofuran-3(1H)-one, a tricyclic clofibrate related lactone having a structural resemblance to mevalonolactone Donald T. Witiak, Eiichi Kuwano, Dennis R. Feller, John R. Baldwin, Howard A. I. Newman, and Shankar K. Sankarappa pp 1214 - 1220; DOI: 10.1021/jm00232a009 |
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3,3-Diphenyl-3-(2-alkyl-1,3,4-oxadiazol-5-yl)propylcycloalkylamines, a novel series of antidiarrheal agents Gilbert W. Adelstein, Chung H. Yen, Esam Z. Dajani, and Robert G. Bianchi pp 1221 - 1225; DOI: 10.1021/jm00232a010 |
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Cinnoline-3-propionic acids, a new series of orally active antiallergic substances David Holland, Geraint Jones, Paul W. Marshall, and Gwenda D. Tringham pp 1225 - 1228; DOI: 10.1021/jm00232a011 |
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Structure of the peptide antibiotic polypeptin John A. Sogn pp 1228 - 1231; DOI: 10.1021/jm00232a012 |
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Investigation of the effect of the solvent medium on the conformational behavior of phenylethylamines by empirical method Mahadevappa Kumbar pp 1232 - 1238; DOI: 10.1021/jm00232a013 |
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Physicochemical-activity relationships in asymmetrical analogues of methoxychlor Peter J. Goodford, Alan T. Hudson, G. Clive Sheppey, Raymond Wootton, Malcolm H. Black, Graeme J. Sutherland, and John C. Wickham pp 1239 - 1247; DOI: 10.1021/jm00232a014 |
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Correlation of opiate receptor affinity with analgetic effects of meperidine homologs Candace B. Pert, Solomon H. Snyder, and Philip S. Portoghese pp 1248 - 1250; DOI: 10.1021/jm00232a015 |
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Charge distribution of histamine monocation in its "essential" conformation W. G. Richards and Jenifer Wallis pp 1250 - 1252; DOI: 10.1021/jm00232a016 |
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Adrenocorticotropin. 49. Synthesis and biological activity of [2-.delta.-aminovaleric acid,5-arginine]adrenocorticotropin-(2-19) James Blake and Choh Hao Li pp 1252 - 1254; DOI: 10.1021/jm00232a017 |
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Pharmacological activity of nitroxide analogs of dichloroisoproterenol and propranolol Elmer J. Rauckman, Gerald M. Rosen, and Robert J. Lefkowitz pp 1254 - 1256; DOI: 10.1021/jm00232a018 |
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Cycloalkanones. 9. Comparison of analogs which inhibit cholesterol and fatty acid synthesis Iris H. Hall and Gerald L. Carlson pp 1257 - 1261; DOI: 10.1021/jm00232a019 |
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Coralyne. Intercalation with DNA as a possible mechanism of antileukemic action W. David Wilson, Alice N. Gough, James J. Doyle, and Michael W. Davidson pp 1261 - 1263; DOI: 10.1021/jm00232a020 |
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Book Reviews pp 1263 - 1264; DOI: 10.1021/jm00232a600 |
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Nucleosides. 1. 9-(3'-Alkyl-3'-deoxy-.beta.-D-ribofuranosyl)adenines as lipophilic analogs of cordycepin. Synthesis and preliminary biological studies Andre Rosowsky, Herbert Lazarus, and Ayako Yamashita pp 1265 - 1270; DOI: 10.1021/jm00233a001 |
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Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli B. Potent inhibition by analogs of N-benzyl-2-phenylethylamine Robert T. Anderson and Daniel V. Santi pp 1270 - 1275; DOI: 10.1021/jm00233a002 |
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Phenylalanyl transfer ribonucleic acid synthetase from rat liver. Analysis of phenylalanine and adenosine 5'-triphosphate binding sites and comparison to the enzyme from Escherichia coli Daniel V. Santi and Robert W. Webster pp 1276 - 1279; DOI: 10.1021/jm00233a003 |
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Evidence for species-specific substrate-site-directed inactivation of rabbit adenylate kinase by N6-(6-iodoacetamido-n-hexyl)adenosine 5'-triphosphate Alexander Hampton, Lewis A. Slotin, and Ram R. Chawla pp 1279 - 1283; DOI: 10.1021/jm00233a004 |
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Active-site-directed alkylation of chymotrypsin by reagents utilizing various departing groups David Larsen and Elliott Shaw pp 1284 - 1286; DOI: 10.1021/jm00233a005 |
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Synthesis of biologically active retroenantiomers of angiotensin peptides Gilberto Goissis, Viviane L. A. Nouailhetas, and Antonio C. M. Paiva pp 1287 - 1290; DOI: 10.1021/jm00233a006 |
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Protein-binding polyhedral boranes. 3 R. L. Jr. Sneath, J. E. Wright, A. H. Soloway, S. M. O'Keefe, A. S. Dey, and W. D. Smolnycki pp 1290 - 1294; DOI: 10.1021/jm00233a007 |
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Polyglutamyl and polylysyl derivatives of the lysine analogs of folic acid and homofolic acid Laurence T. Plante, Elizabeth J. Crawford, and Morris Friedkin pp 1295 - 1299; DOI: 10.1021/jm00233a008 |
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Use of cluster analysis in the development of structure-activity relations for antitumor triazenes W. J. Dunn, M. J. Greenberg, and Soledad S. Callejas pp 1299 - 1301; DOI: 10.1021/jm00233a009 |
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Potential central nervous system antitumor agents. Aziridinylbenzoquinones. 2 Feng-Te Chou, A. Hameed Khan, and John S. Driscoll pp 1302 - 1308; DOI: 10.1021/jm00233a010 |
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Stereochemical studies on medicinal agents. 21. Investigation of the role of conformational factors in the action of diphenylpropylamines. Synthesis and analgetic potency of 5-methylmethadone diastereomers James G. Henkel, Eric P. Berg, and Philip S. Portoghese pp 1308 - 1314; DOI: 10.1021/jm00233a011 |
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Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 1 Victor J. Bauer, Brian J. Duffy, David Hoffman, Solomon S. Klioze, Raymond W. Kosley, Arthur R. McFadden, Lawrence L. Martin, Helen H. Ong, and Harry M. Geyer pp 1315 - 1324; DOI: 10.1021/jm00233a012 |
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Lipid solubility and affinity for N-demethylation of dansylamides in isolated rat hepatocytes J. Scott Hayes and Klaus Brendel pp 1324 - 1328; DOI: 10.1021/jm00233a013 |
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Hashish. 16. Unsaturated side-chain analogs of .DELTA.8-tetrahydrocannabinol with potent biological activity Raj K. Razdan, Haldean C. Dalzell, Patricia Herlihy, and John F. Howes pp 1328 - 1330; DOI: 10.1021/jm00233a014 |
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Cardenolide analogs. 1. A 17.beta.-unsaturated aldehyde Dwight S. Fullerton, Marvin C. Pankaskie, Khalil Ahmed, and Arthur H. L. From pp 1330 - 1333; DOI: 10.1021/jm00233a015 |
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Some novel potential alkylating agents derived from diethylstilbestrol I. M. Roushdi, A. Mohsen, M. E. Omar, M. S. Ragab, and M. Awad pp 1333 - 1336; DOI: 10.1021/jm00233a016 |
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Potential bioreductive alkylating agents. 7. Antitumor effects of phenyl-substituted 2-chloromethyl-3-phenyl-1,4-naphthoquinones Ai Jeng Lin and Alan C. Sartorelli pp 1336 - 1338; DOI: 10.1021/jm00233a017 |
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Preparation and antitumor activities of some derivatives of 5-methoxysterigmatocystin John M. Essery, Frances A. O'Herron, Donald N. McGregor, and William T. Bradner pp 1339 - 1342; DOI: 10.1021/jm00233a018 |
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Synthesis and biological activity of 3,5-dinitro-4- and -2-(1H-purin-6-ylthio)benzoates, prodrugs of 6-mercaptopurine Robert Drawbaugh, Charlene Bouffard, and Michael Strauss pp 1342 - 1345; DOI: 10.1021/jm00233a019 |
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Some 10-substituted 5-ethyl-10-dialkylaminoalkyl-10,11-dihydro-5H-dibenz[b,f]azepines as potential antiarrhythmic agents Charles R. Ellefson and John W. Cusic pp 1345 - 1349; DOI: 10.1021/jm00233a020 |
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Iodo-bis(quaternary ammonium) salts. Potential cartilage-selective x-ray contrast agents Steven P. Van Ootegham, Ronald G. Smith, G. Doyle Daves, Edwin M. Chang, Aziza El-Mazati, George D. Olsen, and William K. Riker pp 1349 - 1352; DOI: 10.1021/jm00233a021 |
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Synthesis and antihypertensive activity of some imidazoindole derivatives P. K. Adhikary, S. K. Das, and B. A. Hess pp 1352 - 1354; DOI: 10.1021/jm00233a022 |
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A circular dichroism study of the interaction of sodium and potassium ions with methionine enkephalin Jacques H. Poupaert, Philip S. Portoghese, and Victor Garsky pp 1354 - 1356; DOI: 10.1021/jm00233a023 |
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Book Reviews pp 1357 - 1358; DOI: 10.1021/jm00233a600 |
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Studies in the design of x-ray contrast agents. Synthesis, hydrophobicity, and solubility of some iodoresorcyl bis(.beta.-glucosides) Frederick L. Weitl, Milos Sovak, Terry M. Williams, and Joseph H. Lang pp 1359 - 1362; DOI: 10.1021/jm00234a001 |
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Iodine-containing organic carbonates as investigative radiopaque compounds B. N. Newton pp 1362 - 1366; DOI: 10.1021/jm00234a002 |
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Pyridoxal phosphate. 5. 2-Formylethynylphosphonic acid and 2-formylethylphosphonic acid, potent inhibitors of pyridoxal phosphate binding and probes of enzyme topography A. J. Rudinskas and T. L. Hullar pp 1367 - 1371; DOI: 10.1021/jm00234a003 |
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Design of substrate-site-directed inhibitors of adenylate kinase and hexokinase. Effect of substrate substituents on affinity for the adenine nucleotide sites Alexander Hampton, Lewis A. Slotin, Francis Kappler, Takuma Sasaki, and Florian Perini pp 1371 - 1377; DOI: 10.1021/jm00234a004 |
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Quinazolines and 1,4-benzodiazepines. 75. 7-Hydroxyaminobenzodiazepines and derivatives Armin Walser, Gladys Zenchoff, and R. Ian Fryer pp 1378 - 1381; DOI: 10.1021/jm00234a005 |
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Stereochemical studies of adrenergic drugs. Optically active derivatives of imidazolines Duane D. Miller, Fu-Lian Hsu, Robert R. Ruffolo, and Popat N. Patil pp 1382 - 1384; DOI: 10.1021/jm00234a006 |
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Preparation, hydrolysis, and oral absorption of lactonyl esters of penicillins J. Peter Clayton, Martin Cole, Stephen W. Elson, Harry Ferres, John C. Hanson, Linda W. Mizen, and Robert Sutherland pp 1385 - 1391; DOI: 10.1021/jm00234a007 |
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Trichothecene analogs. 1. 1,5-Dioxaspiro[2.5]octanes Dwight S. Fullerton, Chi-Ming Chen, and Iris H. Hall pp 1391 - 1395; DOI: 10.1021/jm00234a008 |
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Steroidal 3,5-dienes Philip M. Weintraub, Paul L. Tiernan, Harvey D. Benson, Joyce F. Grunwell, J. O'Neal Johnston, and V. Petrow pp 1395 - 1399; DOI: 10.1021/jm00234a009 |
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Phenylalkylamines with potential psychotherapeutic utility. 1. 2-Amino-1-(2,5-dimethoxy-4-methylphenyl)butane Robert T. Standridge, Henry G. Howell, Jonas A. Gylys, Richard A. Partyka, and Alexander T. Shulgin pp 1400 - 1404; DOI: 10.1021/jm00234a010 |
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Aryl-s-tetrazines with antiinflammatory activity S. A. Lang, B. D. Johnson, E. Cohen, A. E. Sloboda, and E. Greenblatt pp 1404 - 1409; DOI: 10.1021/jm00234a011 |
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Potential antitumor agents. 20. Structure-activity-site relations for the 4'-(9-acridinylamino)alkanesulfonanilides Bruce F. Cain and Graham J. Atwell pp 1409 - 1416; DOI: 10.1021/jm00234a012 |
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Potential antitumor agents. 18. Bisquaternary ammonium heterocycles Bruce F. Cain and Graham J. Atwell pp 1417 - 1419; DOI: 10.1021/jm00234a013 |
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para-Substituted N-acetyl-L(S)- and -D(R)-.alpha.-amino-N-phenylglutarimides. A structure-activity study of substituent effects on stereoselective anticonvulsant activity Donald T. Witiak, Wayne L. Cook, Tribhuwan K. Gupta, and Michael C. Gerald pp 1419 - 1422; DOI: 10.1021/jm00234a014 |
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Carcinogenicity of derivatives of polynuclear compounds Richard M. Peck, Tie Keng Tan, and Evelyn B. Peck pp 1422 - 1423; DOI: 10.1021/jm00234a015 |
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Synthesis and antitumor activity of 4'-deoxydaunorubicin and 4'-deoxyadriamycin Federico Arcamone, Sergio Penco, Silvio Redaelli, and Stephen Hanessian pp 1424 - 1425; DOI: 10.1021/jm00234a016 |
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Additions and Corrections - Synthesis of Substituted 4-Dimethylaminoazobenzenes and a Study of Their Effect on Lactobacillus casei and Escherichia coli. Girgis M. Bebawi, and L. P. Lambooy pp 1425 - 1425; DOI: 10.1021/jm00234a600 |
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Additions and Corrections - ara-Cytidine Acylates. Use of Drug Design Predictors in Structure-Activity Relationship Correlation. W. J. Wechter, M. A. Johnson, C. M. Hall, D. T .Warner, A. E. Berger, A. H. Wenzel, D. T .Gish, and G. L. Neil pp 1425 - 1425; DOI: 10.1021/jm00234a601 |
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Additions and Corrections - Non-Computer Approach to Structure-Activity Study. An Expanded Fibronacci Search Applied to Structurally Diverse Types of Compounds. Norman J. Santora, and King Auyang pp 1425 - 1425; DOI: 10.1021/jm00234a602 |
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Additions and Corrections - Synthesis and Antibacterial Evaluatoin of 1,2,3,4-Tetrahydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Esters, Carbonitriles, and Carboxamides. Arthur A. Santilli, Anthony C. Scotese, and John A. Yurchenco pp 1425 - 1425; DOI: 10.1021/jm00234a603 |
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Additions and Corrections - Quantum Chemical Studies of Merperidine and Prodine. Gilda H. Loew, and J. Randal Jester pp 1425 - 1426; DOI: 10.1021/jm00234a604 |
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Additions and Corrections - Difference in Antimalarial Activity between Certain Amino Alcohol Diastereomers. Ping-Lu Chien, and C. C. Cheng pp 1426 - 1426; DOI: 10.1021/jm00234a605 |
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Additions and Corrections - Cycloalkanones. 8. Hypocholesterolemic Activity of Long-Chain Ketones Related to Pentadecanone. Steven D. Wyrick, Iris H. Hall, C. Piantadosi, and Charles R. Fenske pp 1426 - 1426; DOI: 10.1021/jm00234a606 |
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Additions and Corrections - Novel Pyrazolo, Isoxazolo, and Thiazolo Steroidal Systems and Model Analogs Containing Dimethoxylaryl (or Dihydroxylaryl) Groups and Derivatives. Synthesis, Spectral Properties, and Biological Activity. M. M .Hashem, K. D. Berlin, R. W. Chesnut, and N. N .Durham pp 1426 - 1426; DOI: 10.1021/jm00234a607 |
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Additions and Corrections - Synthesis and Structure-Activity Relationships of Heterocyclic Compounds Containing a Trimethoxyarene Function. E. A. Mawdsley, K. D. Berlin, R. W. Chesnut, and N. N. Durham pp 1426 - 1426; DOI: 10.1021/jm00234a608 |
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Additions and Corrections - Cysteine Derivatives with Reactive Groups as Potential Antitumor Agents. B. Paul, and W. Korytnyk pp 1426 - 1426; DOI: 10.1021/jm00234a609 |